Megumi Hada, Ph.D.




Megumi Hada received her B.S. (1985) and M.S. (1987) in Biology from Shimane University, Japan and her Ph.D. in Biology from Kobe University, Japan (1992). Her graduate work involved UV-B effects on yeast cells. During her postdoctoral and assistant professorship at Kobe University, she worked on UV-induced DNA damage and repair in higher plants. Her research focused on the elucidation of the photo enzymatic repair enzyme. She also worked in the molecular biology and protein engineering field as a research associate at Kyoto University. In 2001, she moved to Brookhaven National Laboratory as a senior research associate and worked on clustered DNA damage induced by heavy ion radiation.

Dr. Hada joined USRA’s Division of Space Life Sciences in 2004 and works in the NASA/JSC Radiation Biodosimetry laboratory. Her current research focuses on DNA damage induced by space radiation to include DNA single and double strand breaks, oxidative damage and chromosome aberrations.


Investigation of switch from ATM to ATR signaling at the sites of DNA damage induced by low and high LET radiation

Estimation of effects of space radiation using frozen mouse ES cells in ISS

Biological effectiveness of accelerated particles for the induction of chromosome damage: track structure effects]

Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways

Chromatin Structure and Radiation-Induced Intrachromosome Exchange

The Correlation of Interphase Chromatin Structure with the Radiation-Induced Inter- and Intrachromosome Exchange Hotspots

Distribution of Chromosome Breakpoints in Human Epithelial Cells Exposed to Low- and High-LET Radiation

Differential Processing of Low and High LET Radiation Induced DNA Damage: Investigation of Switch from ATM to ATR Signaling

The Biological Effectiveness of Four Energies of Neon Ions for the Induction of Chromosome Damage in Human Lymphocytes

High LET Radiation Can Enhance TGF(Beta) Induced EMT and Cross-Talk with ATM Pathways

Non-Target Effect for Chromosome Aberrations in Human Lymphocytes and Fibroblasts After Exposure to Very Low Doses of High LET Radiation

Protons sensitize epithelial cells to mesenchymal transition

Heavy ions can enhance TGFβ mediated epithelial to mesenchymal transition

AT cells are not radiosensitive for simple chromosomal exchanges at low dose

Association of inter- and intrachromosomal exchanges with the distribution of low- and high-LET   radiation-induced breaks in chromosomes

mBAND analysis for high- and low-LET radiation-induced chromosome aberrations: a review

Distributions of Low- and High-LET Radiation-Induced Breaks in Chromosomes are Associated with Inter- and Intrachromosome Exchanges

Pathway Model of the Kinetics of the TGFbeta Antagonist Smad7 and Cross-Talk with the ATM and WNT Pathways

The Biological Effectiveness of Silicon Ions is Significantly Higher than Iron   Ions for the Induction of Chromosome Damage in Human Lymphocytes

DNA Repair Defects and Chromosomal Aberrations

Comparative MicroRNA Expression Patterns in Fibroblasts after Low and High Doses of Low-LET Radiation Exposure

A Human Espophageal Epithelial Cell Model for Study of Radiation Induced Cancer and DNA Damage Repair

Date Updated