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14th Annual Space Radiation Health Investigators' Workshop
April 27–30, 2003
South Shore Harbour Resort and Conference Center
League City, Texas
PRELIMINARY PROGRAM
Sunday, April 27
| 1:00 - 3:30 p.m | Users
Group Pre-Meeting |
Salons A and B |
| 1:00 - 1:30 p.m. | Loma
Linda Proton Synchrotron Facility Overview Gregory Nelson, Loma Linda University |
|
| 1:30 - 2:00 p.m. | Overview
of the NASA Space Radiation Lab (NSRL) D. I. Lowenstein, Brookhaven National Laboratory |
|
| 2:00 - 3:30 p.m. | Review of NSRL Users Manual | |
| 3:30 – 4:30 p.m. | Registration | Hotel Prefunction Area |
| 4:30 - 6:30 p.m. | Scientific Overview Talks | Salons A and B |
| 4:30 - 5:00 p.m. | Animal Models for Carcinogenesis and Aging Larry Donehower, Baylor College of Medicine | |
| 5:00 - 5:30 p.m. | Molecular
Determinants of Cellular Responses to DNA Damage M. B. Kastan, St. Jude Children’s Hospital |
|
| 5:30 - 6:00 p.m. | Beyond
Genomics to Proteomics: the Next Revolution in Molecular Medicine D. J. Johann, Food and Drug Administration |
|
| 6:00 - 6:30 p.m. | Translational
Research Liz Travis, University of Texas M.D. Anderson Cancer Center |
|
| 6:30 – 8:00 p.m. | Reception | Hotel Prefunction Area |
Monday, April 28
| 8:30 - 8:40 a.m. | Welcome Welcome from NASA Chief Scientist Shannon Lucid, Chief Scientist, NASA and Astronaut, STS-51G, STS-34, STS-43, STS-58, and Mir 21 |
Salons A and B |
| 8:40 - 9:10 a.m. | Review
of HZE Radiobiology E. A. Blakely, Lawrence Berkeley National Laboratory |
|
| 9:10 a.m.- Noon | DNA
Damage Processing (All sessions include work in progress as appropriate) |
|
| 9:10 a.m. - 9:40 a.m. | Formation
and Processing of Radiation-Induced Clustered DNA Damage P. O’Neill, Medical Research Council, Harwell, U.K., Radiation and Genome Stability Unit |
|
| 9:40 - 10:00 a.m. | Bistranded
DNA Damage Clusters Induced by Low LET Radiation and Heavy Charged
Particles: Formation and Repairs B. M. Sutherland, Brookhaven National Laboratory |
|
| 10:00 - 10:20 a.m. | Low-Dose
Measurement of DSBs Using a Dual-Label FAR Assay B. Rydberg, Lawrence Berkeley National Laboratory |
|
| 10:20 - 10:40 a.m. | Break | Hotel Prefunction Area |
| 10:40 - 11:00 a.m. | DNA
Fragmentation and Rejoining in Human Cells Exposed to Gamma-rays and
Charged Particles M. Belli, Instituto Superiore di Sanità |
Salons A and B |
| 11:00 - 11:20 a.m. | The
Relation Between DNA-Double Strand Breaks and Mutations Induced by
Heavy Ion Exposure J. Kiefer, Strahlenzentrum, University of Giessen |
|
| 11:20 - 11:40 a.m. | Cytogenetic
Effects of 1 GeV/n Iron Ions Shielded with Different Materials M. Durante, University Federico II |
|
| 11:40 - noon | Truly
Incomplete and Complex Chromosomal Exchanges in Human Fibroblast Cells
Exposed in Situ to Energetic Heavy Ions H. Wu, Wyle Laboratories |
|
| Noon - 12:10 | Poster Overviews | Hotel Prefunction Area |
| 12:10 - 1:30 p.m. | Lunch | Salons C and D |
| 1:30 - 3:20p.m. | Cellular and Tissue Models of Signal Transduction, Aberrant Differentiation, and Apoptosis | Salons A and B |
| 1:30 - 2:00 p.m. | Interaction
Between Tissue and Cellular Stress Responses: TGF-ß 1 is a Key
Mediator of the DNA Damage Response M. H. Barcellos-Hoff, Lawrence Berkeley National Laboratory |
|
| 2:00 - 2:20 p.m. | Response
of Thyroid Tissue Units to Space-Like Radiation Fields L. M. Green, Loma Linda University |
|
| 2:20 - 2:40 p.m. | Apoptotic
Regulation and Mutagenesis in Human Cells Exposed to Charged Particles
of Importance for Spaceflight A. Kronenberg, Lawrence Berkeley National Laboratory |
|
| 2:40 - 3:00 p.m. | LET-Dependence
of the TP53 Response in Human Fibroblasts R. L. Warters, University of Utah Health Sciences |
|
| 3:00 - 3:20 p.m. | Radiation-Induced
Gene Expression in the Nematode C. Elegans G. Nelson, Loma Linda University |
|
| 3:20 - 3:40 p.m. | Break | Hotel Prefunction Area |
| 3:40 - 5:20 p.m. | In-vivo and In-vitro Model of Carcinogenesis | Salons A and B |
| 3:40 - 4:10 p.m. |
Animal Studies of Radiation-Induced Cancer Robert L. Ullrich, Colorado State University |
|
| 4:10 - 4:30 p.m. | Comparison
of Preliminary Results for the Risk of Mammary Carcinogenesis in the
Sprague-Dawley Rat with Previous Experimental Studies J. Dicello, Johns Hopkins University School of Medicine |
|
| 4:30 - 4:50 p.m. | Radiation
Effects in Respiratory Tissues J. Ford, Texas A&M University |
|
| 4:50 - 5:10 p.m. | Proton
and Iron Radiation Effects in Transgenic Mice P. Y. Chang, SRI International |
|
| 5:10 - 5:30 p.m. | Comparative
Studies Between the Effect of Alpha Particles and Heavy Ions in Breast
Carcinogenesis G. Calaf, Columbia University |
|
| 7:00 - 10:00 p.m. | Dinner and Pier Review | Kemah Waterfront |
Tuesday, April 29
| 8:00 - 8:40 a.m. |
Refresher Course Running an Accelerator Experiment (Part I) G. A. Nelson, Loma Linda University |
Salons A and B |
| 8:40 a.m.- 9:50 a.m. | Non-Cancer Effects | |
| 8:40 - 9:10 a.m. | Non-Cancer
Effects: What Are the Risks and the Mechanisms? K. Mabuchi, National Cancer Institute |
|
| 9:10 - 9:30 a.m. | Iron
Ion-, Proton- and X-ray-effects on Human Lens Cell Differentiation P. Y. Chang, SRI International |
|
| 9:30 - 9:50 a.m. | Astronauts,
Exposure to Radiation in Space Flight, and Risk of Cataract L. T. Chylack, Jr., Center for Ophthalmic Research, Brigham and Women's Hospital |
|
| 9:50 - 12:20 p.m. | CNS Radiobology | |
| 9:50 - 10:20 a.m. | Radiation
and Neurogenesis J. R. Fike, University of California, San Francisco |
|
| 10:20 - 10:40 a.m. | Break | Hotel Prefunction Area |
| 10:40 - 11:00 a.m. | Cytotoxicity
of Low- and High-LET Radiation on Neural Cells M. Vazquez, Brookhaven National Laboratory |
Salons A and B |
| 11:00 - 11:20 a.m. | Effects
of Exposure to Different Energies of 56Fe Particles on Neurochemical
and Behavioral Endpoints B. M. Rabin, University of Maryland Baltimore County |
|
| 11:20 - 11:40 a.m. | Putative
Dietary Prevention of the Accelerated Age-Like Effects of Heavy Particle
Irradiation J. Joseph, USDA Human Nutrition Research Center at Tufts University |
|
| 11:40 - Noon | Assessment
of Neuropathology Following 56Fe Exposure by Magnetic Resonance Imaging
and Spectroscopy A. Obenaus, Loma Linda University |
|
| Noon - 12:20 p.m. | The
Proton Radiation Dose Response of the Rat Brain Cortical and White
Matter Vasculature Compared with the Template Measured for Retinal
Vessels J. O. Archambeau, Loma Linda University |
|
| 12:20- 1:30 p.m | Lunch | Salons C and D |
| 1:30 - 4:00 p.m. | Radiation Sensitivity and Prevention Methods | Salons A and B |
| 1:30 - 2:00 p.m. | Identification
of Individuals Susceptible to Normal Tissue Injury After Receiving
Radiotherapeutic Doses of Ionizing Radiation: Development of Predictive
Assays of Clinical Significance M. Story, University of Texas M. D. Anderson Cancer Center |
|
| 2:00 - 2:20 p.m. | Haploinsufficiency
for ATM Confers Radiosensitivity L. B. Smilenov, Columbia University |
|
| 2:20 - 2:40 p.m. | Genetic
Sensitivity and LET Studies of Space Irradiation-induced Genomic Instability
in Vivo M. A. Kadhim, Medical Research Council |
|
| 2:40 - 3:00 p.m. | Countermeasures
for the Biological Effects of Space Radiation A. R. Kennedy, University of Pennsylvania |
|
| 3:00 - 3:20 p.m. | The
Effect of Gamma Irradiation on the Immune Responses of Mice with Polyoma
Virus Infection J. M. Reuben, University of Texas M. D. Anderson Cancer Center |
|
| 3:20 - 3:40 p.m. | Break | Hotel Prefunction Area |
| 3:40 - 4:00 p.m. | Whole-Body
Irradiation and Immune Challenge with a Virus-Derived Antigen D. Gridley, Loma Linda University |
Salons A and B |
| 4:00 - 5:20 p.m. | Computational Models of Risk | |
| 4:00 - 4:20 p.m. | Bystander
Effect and Radiation Risk: A Theoretical Approach H. Nikjoo, MRC, Radiation and Genome Stability Unit |
|
| 4:20 - 4:40 p.m. | Biochemical
Kinetics Model of DSB Processing Competition: NHEJ and HR F. Cucinotta, NASA Johnson Space Center |
|
| 4:40 - 5:00 p.m. | The
Two-Stage Clonal Expansion Model of Cancer S. B. Curtis, Fred Hutchinson Cancer Research Center |
|
| 5:00 - 5:20 p.m. | Application
of the Local Effect Model to Calculate Cell Transformation After High-LET
Radiation M. Scholz, GSI/Biophysics |
|
| 6:15 - 7:00 p.m. | Buses Transport Workshop Participants to Space Center Houston | |
| 7:00 - 10:00 p.m. | Dinner
Banquet Plenary Talk Franklin R. Chang-Diaz Director, Advanced Space Propulsion Laboratory, NASA Johnson Space Center and NASA Astronaut, STS 61-C (1986), STS-34 (1989), STS-46 (1992), STS-60 (1994), STS-75 (1996), STS-91 (1998), and STS-111 (2002) |
Space Center Houston |
Wednesday, April 30
| 8:00 - 8:40 a.m. |
Refresher Course How to Do an Accelerator Experiment, Part II: Physics Considerations C. Zeitlin, Lawrence Berkeley National Laboratory |
Salons A and B |
| 8:40 - 10:15 a.m. | Radiation Critical Path Roadmap (CPR) | |
| 8:40 - 9:00 a.m. | Overview
of Bioastronautics Critical Path Roadmap L. Leveton and J. Charles |
|
| 9:00 - 10:15 a.m. | Panel
Discussion Critical Path Roadmap for Radiation Health Research |
|
| 10:15 - 10:30 a.m. | Break | Hotel Prefunction Area |
| 10:30 - 10:50 a.m. | Physics and Dosimetry | Salons A and B |
| 10:30 - 10:50 a.m. | One
Year of Results from the Martian Radiation Environment Experiment
(MARIE) C. Zeitlin, Lawrence Berkeley National Laboratory |
|
| 10:50 - 11:05 a.m. | MARIE Observations
of Solar Particle Events R. Turner, ANSER |
|
| 11:05 - 11:20 a.m. | A New LEO
ISS Environmental Model J. W. Wilson, NASA Langley Research Center |
|
| 11:20 - 11:35 a.m. | Measurements
of Radiation Transport in Materials Used in Human Space Flight J. Miller, Lawrence Berkeley National Laboratory |
|
| 11:35 - 11:50 a.m. | Study
of the Fluence and LET Distribution of Projectile Fragments Produced
from Heavy Ion Therapeutic Beams M. Komori, National Institute of Radiological Science (NIRS) |
|
| 11:50 - 12:05 p.m. | Neutron
Dosimetry Using Tissue Equivalent and a Silicon Equivalent Proportional
Counters for Eight High-Energy Neutron Spectra B. Gersey, Prairie View A&M University |
|
| 12:05 - 12:20 p.m. | Microdosimetry
of Heavy Ions with Different Energies but with Similar LET T. Borak, Colorado State University |
|
| 12:20 - 12:35 p.m. | Preliminary
Results from the First Three ICCHIBAN Intercomparisons of Space Radiation
Detectors E. Benton, Eril Research, Inc. |
|
| 12:35 p.m. | Workshop Adjourns | |
|
Posters The Number
and Reaction Multiplicities of GCR Nuclei and Delta-rays Passing
Through a Cell Nucleus on a Mars Mission The Effects
of Whole-Body Gamma Irradiation on the Immune Response to LPS Model Calculations
and Visualization of GCR Particle Flux on the Surface of Mars Development
of Collaborative Engineering Environments for Spacecraft Design
Changes
in Cocaine-Induced Locomotor Activity After Exposure to 1 GeV/n
Fe Ions and Gamma Rays Dose Distribution
in Critical Body Organs: Phantom Torso Experiment (PTE) During the
ISS Increment 2 Mission Simulation
of Proton Beamline with MCNPX The Non-Invasive
Imaging Laboratory at Loma Linda University: a Resource for NASA
Scientists Advances
in Space Radiation Transport Codes Quantification
of Radiation-induced Proteins Using the Luminex 100™ System A Proton
Beam Delivery System for Solar Flare Simulations at LLUMC Detection
of ?-H2AX Foci Formation in Human Peripheral Blood Lymphocytes Exposed
to Accelerated Charged Particles TEPC's Overestimate
the Average Quality Factor for Trapped Protons and Underestimate
the Average Quality Factor for GCR Free Flyers:
A Research Platform to Augment the International Space Station |
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Last
updated March 18, 2003