Publications

 

Follow link to listed abstract or publication.

 


Chappell, Lori

NASA Models of Space Radiation Induced Cancer, Circulatory Disease, and Central Nervous System Effects


How safe is safe enough? Radiation risk for a human mission to Mars


Biological effectiveness of accelerated particles for the induction of chromosome damage: track structure effects


Space Radiation Cancer Risk Projections and Uncertanities - 2010


Radiation Carcinogenesis Risk Assessments for Never-smokers


NASCA report 2: Longitudinal study of relationship of exposure to space radiation and risk of lens opacity


Updates to astronaut radiation limits: radiation risks for never-smokers


Persistence of space radiation induced cytogenetic damage in the blood lymphocytes of astronauts


Analysis of Flow Cytometry DNA Damage Response Protein Activation Kinetics after Exposure to X Rays and High-Energy Iron Nuclei


Non-targeted effects and the dose response for heavy ion tumor induction


Space Radiation Cancer, Circulatory Disease and CNS Risks for Near Earth Asteroid and Mars Missions: Uncertainty Estimates for Never-Smokers


Space Radiation Heart Disease Risk Estimates for Lunar and Mars Missions


Non-Targeted Effects and the Dose Response for Heavy Ion Tumorigenesis


Probability of Causation for Space Radiation Carcinogenesis Following International Space Station, Near Earth Asteroid, and Mars Missions

   

Conkin, Johnny

Equivalent Air Altitude and the Alveolar Gas Equation


Hypobaric Decompression Sickness Treatment Model


Modeling a 15-min extravehicular activity prebreathe protocol using NASA׳s exploration atmosphere (56.5 kPa/34% O2)


Probabilistic Assessment of Hypobaric Decompression Sickness Treatment Success


Ambulation Increases Decompression Sickness in Altitude Exposure


Evidence Report: Risk of Decompression Sickness (DCS)


Gernhardt ML, Dervay JP, Waligora JM, Fitzpatrick DT, Conkin J.  (2013) Extravehicular Activities (Chap. 5.4). In: Biomedical Results of the Space Shuttle Program, Risin D, Stepaniak PC (eds.),  Washington DC: U.S. Government Printing Office, NASA/SP-2013-607. ISBN: 978-0-615-86613-0., pp. 315-26


Fifteen-minute Extravehicular Activity Prebreathe Protocol Using NASA's Exploration Atmosphere (8.2 psia/ 34% 02)


Probability of hypobaric decompression sickness including extreme exposures


Accuracy of Physiological Altitude Simulation


Protective mechanisms in hypobaric decompression


Comments on Point: Counterpoint: Hypobaric hypoxia induces/does not induce different responses from normobaric hypoxia


PH2O and simulated hypobaric hypoxia


Decompression sickness after air break in prebreathe described with a survival model


Air break during preoxygenation and risk of altitude decompression sickness


Defining Nitrogen Kinetics for Air Break in Prebreath

   

Cromwell, Ronita

Effects of sex and gender on adaptation to space: neurosensory systems


Ocular outcomes evaluation in a 14-day head-down bed rest study


Countermeasures and Functional Testing in Head-Down Tilt Bed Rest (CFT 70)


Sensorimotor Adaptation Training's Effect on Head Stabilization in Response to a Lateral Perturbation in Older Adults


Spaceflight Analogs


Association Between Cardiovascular and Intraocular Pressure Changes in a 14-Day 6 deg Head Down Tilt (HDT) Bed Rest Study: Possible Implications in Retinal Anatomy


Effects of 30-Day Head-Down Bed Rest on Ocular Structures and Visual function in a Healthy Subject


The effect of microgravity on ocular structures and visual function: a review


Evaluation of Ocular Outcomes in Two 14-day Bed Rest Studies


Recent Results from NASA Bed Rest Studies


Long Duration Head-Down Tilt Bed Rest Studies: Safety Considerations Regarding Vision Health


Bed Rest is an Analog to Study the Physiological Changes of Spaceflight and to Evaluate Countermeasures


Outcome measure to assess head-down bed rest subject performance


Functional Mobility Performance and Balance Confidence in Older Adults after   Sensorimotor Adaptation Training


Feasibility Study of a Lunar Analog Bed Rest Model


International Standardization of Bed Rest Standard Measures


Comparison of Ocular Outcomes in Two 14-Day Bed Rest Studies

   

Fielder, James

The metabolic cost of an integrated exercise program performed during 14 days of bed rest


Getting More from (Small-n) Research Data: Getting Clinical instead of Cynical


Statistics Clinic


Last word on viewpoint: justifying small-n research in scientifically amazing settings: challenging the notion that only "big-n" studies are worthwhile]


Justifying small-n research in scientifically amazing settings: Challenging the notion that only "big-n" studies are worthwhile


The metabolic cost of an integrated exercise program performed during 14 days of bed rest


Justifying small-n research in scientifically amazing settings: Challenging the notion that only "big-n" studies are worthwhile


Re-imaging a Stata / Python Combination


Imagining a Stata / Python Combination


Interactive Web Graphs with Fewer Restrictions


FDR doesn't Tell the Whole Story: Joint Influence of Effect Size and Covariance Structure on the Distribution of the False Discovery Proportions


Influence of muscle strength to weight ratio on functional task performance


Joint modeling of performance and subjective reporting to assess sensitivity to drug-induced sleepiness


Locomotor function after long-duration space flight: effects and motor learning during recovery


Novel Analog For Muscle Deconditioning


Pre/Post Data Analysis — Simple or Is It?


Statistical Challenges in Biomedical Research

   

Hada, Megumi

Investigation of switch from ATM to ATR signaling at the sites of DNA damage induced by low and high LET radiation


Estimation of effects of space radiation using frozen mouse ES cells in ISS


Biological effectiveness of accelerated particles for the induction of chromosome damage: track structure effects]


Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways


Chromatin Structure and Radiation-Induced Intrachromosome Exchange


The Correlation of Interphase Chromatin Structure with the Radiation-Induced Inter- and Intrachromosome Exchange Hotspots


Distribution of Chromosome Breakpoints in Human Epithelial Cells Exposed to Low- and High-LET Radiation


Differential Processing of Low and High LET Radiation Induced DNA Damage: Investigation of Switch from ATM to ATR Signaling


The Biological Effectiveness of Four Energies of Neon Ions for the Induction of Chromosome Damage in Human Lymphocytes


High LET Radiation Can Enhance TGF(Beta) Induced EMT and Cross-Talk with ATM Pathways


Non-Target Effect for Chromosome Aberrations in Human Lymphocytes and Fibroblasts After Exposure to Very Low Doses of High LET Radiation


Protons sensitize epithelial cells to mesenchymal transition


Heavy ions can enhance TGFβ mediated epithelial to mesenchymal transition


AT cells are not radiosensitive for simple chromosomal exchanges at low dose


Association of inter- and intrachromosomal exchanges with the distribution of low- and high-LET   radiation-induced breaks in chromosomes


mBAND analysis for high- and low-LET radiation-induced chromosome aberrations: a review


Distributions of Low- and High-LET Radiation-Induced Breaks in Chromosomes are Associated with Inter- and Intrachromosome Exchanges


Pathway Model of the Kinetics of the TGFbeta Antagonist Smad7 and Cross-Talk with the ATM and WNT Pathways


The Biological Effectiveness of Silicon Ions is Significantly Higher than Iron   Ions for the Induction of Chromosome Damage in Human Lymphocytes


DNA Repair Defects and Chromosomal Aberrations


Comparative MicroRNA Expression Patterns in Fibroblasts after Low and High Doses of Low-LET Radiation Exposure


A Human Espophageal Epithelial Cell Model for Study of Radiation Induced Cancer and DNA Damage Repair

   

Hu, Shaowen

Epidermal homeostasis and radiation responses in a multiscale tissue modeling framework


A Multiscale Computational Model of the Response of Swine Epidermis After Acute Irradiation


Space Radiation Cancer Risk Projections and Uncertainties - 2010


Acute Radiation Risk and BRYNTRN Organ Dose Projection Graphical User Interface


Atomistic Simulations of Complex DNA DSBs and the Interactions with Ku70/80 Heterodimer


Modeling Acute Health Effects of Astronauts from Exposure to Large Solar Particle Events


Interactions of Ku70/80 with Double-Strand DNA: Energetic, Dynamics, and Functional Implications


A biomathematical model of lymphopoiesis following severe radiation accidents--potential use for dose assessment


Putative binding modes of Ku70-SAP domain with double strand DNA: a molecular modeling study


Computational studies on full-length Ku70 with DNA duplexes: base interactions and a helical path


Characterization of the radiation-damaged precursor cells in bone marrow based on modeling of the peripheral blood granulocytes response


Modelling the way Ku binds DNA


A cell kinetic model of granulopoiesis under radiation exposure: extension from rodents to canines and humans


Overview of Graphical User Interface for ARRBOD (Acute Radiation Risk and BRYNTRN Organ Dose Projection)


Development of Graphical User Interface for ARRBOD (Acute Radiation Risk and BRYNTRN Organ Dose Project)


A biomathematical model of lymphopoiesis following severe radiation accidents-potential use for dose assessment

   

Huff, Janice L

Effects of sex and gender on adaptation to space: immune system


Space Radiation and Risks to Human Health


Radiation Effects on Tissue Differentiation in a 3-D Organotypic Aerodigestive Tract Model


NASA Human Research Program Space Radiation Program Element


How safe is safe enough? Radiation risk for a human mission to Mars


Biological effectiveness of accelerated particles for the induction of chromosome damage: track structure effects


Ionizing Radiation Enhances Esophageal Epithelial Cell Migration and Invasion Through a Paracrine Mechanism Involving Stromal-Derived Hepatocyte Growth Factor


High LET Radiation Can Enhance TGF(Beta) Induced EMT and Cross-Talk with ATM Pathways


Heavy ions can enhance TGFβ mediated epithelial to mesenchymal transition


AT cells are not radiosensitive for simple chromosomal exchanges at low dose


Dendro[C(60)]fullerene DF-1 provides radioprotection to radiosensitive mammalian cells


The analysis of the densely populated patterns of radiation-induced foci by a stochastic, Monte Carlo model of DNA double-strand breaks induction by heavy ions


Acute Radiation Syndromes Risk Revised MLDs


Influence of Ionizing Radiation on Stromal-Epithelial Intercellular Communication in Esophageal Carcinogenesis


Pathway Model of the Kinetics of the TGFbeta Antagonist Smad7 and Cross-Talk with the ATM and WNT Pathways


A Human Espophageal Epithelial Cell Model for Study of Radiation Induced Cancer and DNA Damage Repair


Heavy Ions Can Enhance TGFβ Mediated Epithelial to Mesenchymal Transition


DNA Repair Defects and Chromosomal Aberrations

   

Kidane, Yared

Computational approaches for discovery of common immunomodulators in fugal infections: towards broad-spectrum immunotherapeutic interventions


The landscape of host transcriptional response programs commonly perturbed by bacterial pathogens: towards host-oriented broad-spectrum drug targets

   

Kim, Myung-Hee

Simulation and Comparison of Martian Surface Ionization Radiation


NASA Models of Space Radiation Induced Cancer, Circulatory Disease, and Central Nervous System Effects


Co-expression of monodehydroascorbate reductase and dehydroascorbate reductase from Brassica rapa effectively confers tolerance to freezing-induced oxidative stress


How safe is safe enough? Radiation risk for a human mission to Mars


Modeling Acute Health Effects of Astronauts from Exposure to Large Solar Particle Events


Space Radiation Cancer Risks and Uncertainities for Different Mission Time Periods


Space Radiation Cancer Risk Projections and Uncertanities - 2010


Radiation Carcinogenesis Risk Assessments for Never-smokers


Description of transport codes for space radiation shielding


Space Radiation Cancer, Circulatory Disease and CNS Risks for Near Earth  Asteroid and Mars Missions: Uncertainty Estimates for Never-Smokers


Nuclear interactions in heavy ion transport and event-based risk models


Probabilistic assessment of radiation risk for astronauts in space missions  Original Research Article


Comparison of organ dose and dose equivalent for human phantoms of CAM vs. MAX  Original Research Article


Statistical Projection of Solar Cycle 24 for the Exposure Estimates


Space Radiation Heart Disease Risk Estimates for Lunar and Mars Missions


Overview of the Graphical User Interface for the GERMcode (GCR Event-Based Risk Model)


Development of Graphical User Interface for ARRBOD (Acute Radiation Risk and BRYNTRN Organ Dose Project


Probability of Causation for Space Radiation Carcinogenesis Following International Space Station, Near Earth Asteroid, and Mars Missions


Development of a GCR Event-based Risk Model


Transmission of galactic cosmic rays through Mars atmosphere


A Stochastic Model of Space Radiation Transport as a Tool in the Development of Time-Dependent Risk Assessment


Vehicle Shield Optimization and Risk Assessment for Future Human Space Missions

   

Li, Yongfeng

Modeling non-homologous end joining


Nonlinear Oscillation and Multiscale Dynamics in a Closed Chemical Reaction


A stochastic model of DNA fragments rejoining


Modularized Smad-regulated TGFβ signaling pathway


A generic model for open signaling cascades with forward activation


Open cascades as simple solutions to providing ultrasensitivity and adaptation in cellular signaling

   

McPhee, Jancy

International Humans in Space Symposium Youth Art Competition, Biennial Research and Technology Report

   

Mulavara, Ajitkuman

Exercise as potential countermeasure for the effects of 70 days of bed rest on cognitive and sensorimotor performance


Exercise as potential countermeasure for the effects of 70 days of bed rest on cognitive and sensorimotor performance


Exercise as potential countermeasure for the effects of 70 days of bed rest on cognitive and sensorimotor performance


Using low levels of stochastic vestibular stimulation to improve locomotor stability


Using Low Levels of Stochastic Vestibular Stimulation to Improve Balance Function


Individual predictors of sensorimotor adaptability


Effects of Stochastic Vestibular Galvanic Stimulation and LDOPA on Balance and Motor Symptoms in Patients With Parkinson's Disease


Reschke MF, Clément G, Thorson SL, Mader T, Dudley AM, Wood SJ, Bloomberg JJ, Mulavara AP, Gibson CR, and Williams D. In: Section III: Space Flight and Crew Health: Adaptation, Pathophysiology, Rehabilitation, and Countermeasures, Chapter 9, Neurology. Space Physiology and Medicine (Ed. A Nicogossian)


Screening people in the waiting room for vestibular impairments


Focal Gray Matter Plasticity as a Function of Long Duration Head-down Tilt Bed Rest


Improving Early Adaptation Following Long Duration Spaceflight by Enhancing Vestibular Information


Functional Imaging of Human Vestibular Cortex Activity Elicited by Skull Tap and Auditory Tone Burst


Understanding the Effects of Long-duration Space Flight on Astronant Functional Task Performance


Study protocol to examine the effects of spaceflight and a spaceflight analog on neurocognitive performance: extent, longevity, and neural bases


Sharpening the tandem walking test for screening peripheral neuropathy


Standing balance tests for screening people with vestibular impairments


Adaptation in locomotor stability, cognition, and metabolic cost during sensory discordance


New analyses of the sensory organization test compared to the clinical test of sensory integration and balance in patients with benign paroxysmal positional vertigo


Posturography and locomotor tests of dynamic balance after long-duration spaceflight


Improving Balance Function Using Low Levels of Electrical Stimulation of the Balance Organs


Enhancement of Otolith Specific Ocular Responses Using Vestibular Stochastic Resonance


Development of Vestibular Stochastic Resonance as a Sensorimotor Countermeasure: Improving Otolith Ocular and Motor Task Responses


Vestibular-somatosensory convergence in head movement control during locomotion after long-duration space flight


Dynamic visual acuity testing for screening patients with vestibular impairments


Tests of walking balance for screening vestibular disorders


Gait adaptability training is affected by visual dependency


Changes in toe clearance during treadmill walking after long-duration spaceflight


Test battery designed to quickly and safely assess diverse indices of neuromuscular function after unweighting


Gait training improves performance in healthy adults exposed to novel sensory discordant conditions


Improving balance function using vestibular stochastic resonance: optimizing stimulus characteristics


Dynamic visual acuity during walking after long-duration spaceflight


Locomotor function after long-duration space flight: effects and motor learning during recovery


Sensory Bias Predicts Postural Stability, Anxiety, and Cognitive Performance in Healthy Adults Walking in Novel Discordant Conditions


Influence of Sensory Dependence on Postural Control


Visual Performance Challenges to Low-Frequency Perturbations After Long-Duration Space Flight, and Countermeasure Development


The Role of Adaptation in Body Load-Regulating Mechanisms During Locomotion


Reliability of a Test Battery Designed for Quickly and Safely Assessing Diverse Indices of Neuromuscular Function


Training Modalities to Increase Sensorimotor Adaptability


Defining the Physiological Factors that Contribute to Postflight Changes in Functional Performance

   

Mulugeta, Lealem

Microgravity-induced fluid shift and ophthalmic changes


Evaluating Daily Load Stimulus Formulas in Relating bone Response to Exercise


Microgravity-Induced Fluid Shift and Ophthalmic Changes


The Digital Astronaut Project Bone Remodeling Model


Uncertainty, Validation and Sensitivity Analyses of the OpenSim Muscle Model for Pre- and Post-Flight Strength Predictions


Verification, Validation and Credibility Assessment of a Computational Model of the Advanced Resistive Exercise Device (ARED)


Development of a Pulsed 2-Micron Integrated Path Differential Absorption Lidar for CO2 Measurement


The Digital Astronaut Project Computational Bone Remodeling Model (Beta Version) Bone Summit Summary Report


The Value of Biomedical Simulation Environments to Future Human Space Flight Missions


Models of the Eye: Relevance to Microgravity Induced Visual Impairment and Intracranial Pressure


Computational Models of the Eye and their Applications in Long Duration Space Flight

   

Norsk, Peter

Body height and arterial pressure in seated and supine young males during +2 G centrifugation


Fluid shifts, vasodilatation and ambulatory blood pressure reduction during long duration spaceflight


Circulatory responses to lower body negative pressure in young Afghans and Danes: implications for understanding ethnic effects on blood pressure regulation


Blood pressure regulation IV: adaptive responses to weightlessness


Blood pressure in Afghan male immigrants to Denmark


Mechanisms and management of exercise-induced asthma in elite athletes


NASA's Current Evidence and Hypothesis for the Visual Impairment and Intracranial Pressure Risk


Human Cardiovascular Adaptation to Short-Term Weightlessness


Human Research Program Human Health Countermeasures Element Overview


Human Cardiovascular Adaptation to Weightlessness


Mechanisms of increase in cardiac output during acute weightlessness in humans


Impact of diuretic treatment and sodium intake on plasma volume in patients with compensated systolic heart failure


Estimating changes in cardiac output using an implanted hemodynamic monitor in heart failure patients


Body height and blood pressure regulation in humans during anti-orthostatic tilting


Human Health Countermeasures (HHC) Element Management Plan: Human Research Program

   

Nounu, Hatem

Vehicle Shield Optimization and Risk Assessment of Future NEO Missions


A Stochastic Model of Space Radiation Transport as a Tool in the Development of Time-Dependent Risk Assessment


Vehicle Shield Optimization and Risk Assessment for Future Human Space Missions


Overview of Graphical User Interface for ARRBOD (Acute Radiation Risk and BRYNTRN Organ Dose Projection)


Development of Graphical User Interface for ARRBOD (Acute Radiation Risk and BRYNTRN Organ Dose Projection)

   

Otto, Christian

[url=http://www.ncbi.nlm.nih.gov/pubmed/26828842]Neuro-Opthalmology of Space Flight[url]


Mr-derived cerebral spinal fluid hydrodynamics as a marker and a risk factor for intracranial hypertension in astronauts exposed to microgravity


Monitoring Long-term Effects on Vision in Microgravity a Priority for NASA's Future Flight to Mars


Evaluation of Tele-ultrasound as a tool in remote diagnosis and clinical management at the Admundsen-Scott South Pole Station and the McMurdo Research Station


NASA's Current Evidence and Hypothesis for the Visual Impairment and Intracranial Pressure Risk


Real-time tele-echocardiography: diagnosis and management of a pericardial effusion secondary to pericarditis at an Antarctic research station


Countermeasures to Mitigate the Negative Impact of Sensory Deprivation and Social Isolation in Long-Duration Space Flight


Risk of Microgravity-Induced Visual Impairment and Elevated Intracranial Pressure (VIIP)


Perspectives on Asthenia in Astronauts and Cosmonauts: Review of the  International Research Literature


Different Perspectives on Asthenia in Astronauts and Cosmonauts: International Research Literature


The Martian chronicles: remotely guided diagnosis and treatment in the Arctic Circle

   

Patel, Zarana

Summer Research Paper


Influence ofIonizing Radiation on Stromal-Epithelial Intercellular Communication in Esophageal Carcinogenesis


AT cells are not radiosensitive for simple chromosomal exchanges at low dose.


Ionizing Radiation Enhances Esophageal Epithelial Cell Migration and Invasion Through a Paracrine Mechanism Involving Stromal-Derived Hepatocyte Growth Factor


A Human Espophageal Epithelial Cell Model for Study of Radiation Induced Cancer and DNA Damage Repair

   

Pellis, Neal

An Evidence Base for Human Spaceflight Risks in Wikipedia


A three-dimensional tissue culture model of bone formation utilizing rotational co-culture of human adult osteoblasts and osteoclasts


Risin D, Crucian BE, Mehta SK, Pellis NR, Pierson DL, Sams CF. (2013) Immune System (Chapter 4.12). In: Biomedical Results of the Space Shuttle Program, Risin D, Stepaniak PC (eds.), Washington DC: U.S. Government Printing Office, NASA/SP-2013-607. ISBN: 978-0-615-86613-0. pp. 245-257

   

Picano, James

Total force fitness: the military family fitness model

   

Plante, Ianik

A Binary-Encounter-Bethe Approach to Simulate DNA Damage by the Direct Effect


A Radiation Chemistry Code Based on the Green's Functions of the Diffusion Equation


A Green's Function Approach to Simulate DNA Damage by the Indirect Effect


Participation of gap junction communication in potentially lethal damage repair and DNA damage in human fibroblasts exposed to low- or high-LET radiation


Calculation of the energy deposition in nanovolumes by protons and HZE particles: geometric patterns of initial distributions of DNA repair foci


Development of the Code RITRACKS, NASA Tech Brief


Gap junction communication and the propagation of bystander effects induced by microbeam irradiation in human fibroblast cultures: the impact of radiation quality


Galactic Cosmic Ray Event-Based Risk Model (GERM) Code- NASA Technical Report


Calculation of the Frequency Distribution of the Energy Deposition in DNA Volumes by Heavy Ions


Energy deposition and  relative frequency of hits of cylindrical nanovolume in medium irradiated by  ions: Monte Carlo simulation of tracks structure


A Monte-Carlo step-by-step simulation code of the non-homogeneous chemistry of the radiolysis of water and aqueous solutions-Part II: calculation of radiolytic yields under different conditions of LET, pH, and temperature


A Monte-Carlo step-by-step simulation code of the non-homogeneous chemistry of the radiolysis of water and aqueous solutions. Part I: theoretical framework and implementation


Step-by-Step Simulation Chemistry Using Green Functions for Diffusion-Influenced Reactions


Monte-Carlo simulation of ionizing radiation tracks in the book "Applications of Monte Carlo Methods in Biology, Medicine and Other Fields of Science"


Radiation chemistry primer. This article is posted on the THREE web site.


Model of the initiation of signal transduction by ligands in a cell culture: Simulation of molecules near a plane membrane comprising receptors


Nuclear interactions in  heavy ion transport and event-based risk models


Simulation of TGF-Beta Activation by Low-Dose HZE Radiation in a Cell Culture


Development of a GCR Event-based Risk Model


3D Visualization of Monte-Carlo Simulations of HZE Track Structure and Initial Chemical Species

   

Ploutz-Snyder, Lori

Exercise as potential countermeasure for the effects of 70 days of bed rest on cognitive and sensorimotor performance


Evaluating Countermeasures in Spaceflight Analogs


Isokinetic Strength Changes Following Long-Duration Spaceflight on the ISS


The Astronaut-Athlete: Optimizing Human Performance in Space


Reliability of a new test battery for fitness assessment of the European Astronaut corps


Exercise as potential countermeasure for the effects of 70 days of bed rest on cognitive and sensorimotor performance


Effects of sex and gender on adaptation to space: musculoskeletal health


Peak exercise oxygen uptake during and following long-duration spaceflight


Ground reaction forces during treadmill running in micro


The metabolic cost of an integrated exercise program performed during 14 days of bed rest


Bungee force level, stiffness, and variation during treadmill locomotion in simulated microgravity


Acute vascular and cardiovascular responses to blood flow-restricted exercise


The metabolic cost of an integrated exercise program performed during 14 days of bed rest


Neuromuscular function following muscular unloading and blood flow restricted exercise


Sildenafil Increases Muscle Protein Synthesis and Reduces Muscle Fatigue


A ground-based comparison of the Muscle Atrophy Research and Exercise System (MARES) and a commercially available isokinetic dynamometer


Analog Exercise Hardware to Implement a High Intensity Exercise Program During Bed Rest


Integrated Resistance and Aerobic Training Maintains Cardiovascular and Skeletal Muscle Fitness During 14 Days of Bed Rest


Novel Analog For Muscle Deconditioning


Skeletal muscle volume following dehydration induced by exercise in heat


Benefits for bone from resistance exercise and nutrition in long-duration spaceflight: Evidence from biochemistry and densitometry


Influence of muscle strength to weight ratio on functional task performance


Lumbar Muscle Activity during Common Lifts: a Preliminary Study using Magnetic Resonance Imaging


Reliability and validity of panoramic ultrasound for muscle quantification


Lower-extremity force decrements identify early mobility decline among community-dwelling older adults


Muscle Adaptations Following Short-Duration Bed Rest with Integrated Resistance, Interval, and Aerobic Exercise


The effect of progressive resistance training on leg strength, aerobic capacity and functional tasks of daily living in persons with Down syndrome


The metabolic costs of reciprocal supersets vs. traditional resistance exercise in young recreationally active adults


Physical fitness predicts functional tasks in individuals with Down syndrome


Short-term training effects on diastolic function in obese persons with the metabolic syndrome


Scientific literacy and attitudes towards American space exploration among college undergraduates, an Original Research Article


Nutrition and resistance exercise during reconditioning from unloading


Unilateral lower limb suspension: integrative physiological knowledge from the past 20 years (1991-2011)


Test battery designed to quickly and safely assess diverse indices of neuromuscular function after unweighting


Relationships Among Lower Body Strength, Power and Performance of Functional Tasks


Reliability of a Test Battery Designed for Quickly and Safely Assessing Diverse Indices of Neuromuscular Function


Cutting Edge Training and Testing Technologies for Occupations with Unique Physical Demands: Optimizing Astronaut Performance for Long Duration Spaceflight

   

Ploutz-Snyder, Robert

Leucine partially protects muscle mass and function during bed rest in middle-aged adults


Isokinetic Strength Changes Following Long-Duration Spaceflight on the ISS


Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes


Hypobaric Decompression Sickness Treatment Model


Effect of Aspirin Supplementation on Hemodynamics in Older Firefighters


Breast Milk as a Potential Source of Epstein-Barr Virus Transmission Among Infants Living in a Malaria-Endemic Region of Kenya


The metabolic cost of an integrated exercise program performed during 14 days of bed rest


Probabilistic Assessment of Hypobaric Decompression Sickness Treatment Success


Ocular outcomes evaluation in a 14-day head-down bed rest study


Plasmodium falciparum Infection is Associated with Epstein-Barr Virus Reactivation in Pregnant Women Living in Malaria Holoendemic Area of Western Kenya


Last word on viewpoint: justifying small-n research in scientifically amazing settings: challenging the notion that only "big-n" studies are worthwhile]


Justifying small-n research in scientifically amazing settings: Challenging the notion that only "big-n" studies are worthwhile


The metabolic cost of an integrated exercise program performed during 14 days of bed rest


Association Between Cardiovascular and Intraocular Pressure Changes in a 14-Day 6 deg Head Down Tilt (HDT) Bed Rest Study: Possible Implications in Retinal Anatomy


Integrated Resistance and Aerobic Training Maintains Cardiovascular and Skeletal Muscle Fitness During 14 Days of Bed Rest


Long Duration Head-Down Tilt Bed Rest Studies: Safety Considerations Regarding Vision Health


Mechanical Stress and Antioxidant Protection in the Retina of Hindlimb Suspended Rats


Defining the Relationship between Biomarkers of Oxidative and Inflammatory Stress and the Risk for Atherosclerosis in Astronauts during and after Long-Duration Spaceflight


Influence of muscle strength to weight ratio on functional task performance


Bone Metabolism and Nutritional Status during 30-day Head-Down Tilt Bed Rest


Development of head injury assessment reference values based on NASA injury modeling


Reliability and validity of panoramic ultrasound for muscle quantification


Gait adaptability training is affected by visual dependency


Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism


Family physician attitudes in managing obesity: a cross-sectional survey study</a></td>


Psychiatric and substance use disorders among methadone maintenance patients with chronic hepatitis C infection: effects on eligibility for hepatitis C treatment


Telemedicine intervention effects on waist circumference and body mass index in the IDEATel project


Accuracy of self-reported medical problems in patients with alcohol dependence and co-occurring schizophrenia or schizoaffective disorder


Predictors of smoking severity in patients with schizophrenia and alcohol use disorders


Promoting couples collaboration in type 2 diabetes: the diabetes support project pilot data


Response to vitamin D intake: from the Antarctic to the Institute of Medicine


Response to vitamin D supplementation during Antarctic winter is related to BMI, and supplementation can mitigate Epstein-Barr Virus Reactivation


Gait training improves performance in healthy adults exposed to novel sensory discordant conditions


Changes in toe clearance during treadmill walking after long-duration spaceflight


Hepatitis C treatment eligibility and comorbid medical illness in methadone maintenance (MMT) and non-MMT patients: a case-control study


Use of three computer training methods in elderly underserved rural patients enrolled in a diabetes telemedicine program


Pre/Post Data Analysis — Simple or Is It?


SMAR Sessions


Math:The Gateway to Great Careers


Skeletal benefits of pre-menarcheal gymnastics are retained after activity cessation


Radioadaptive Cytoprotective Pathways in the Mouse Retina


Early age at time of primary Epstein-Barr virus infection results in poorly controlled viral infection in infants from Western Kenya: clues to the etiology of endemic Burkitt lymphoma


To boldly and safely go: Biostatistics in space (2012) Significance: Statistics Making Sense

   

Ponomarev, Artem

Calculation of the energy deposition in nanovolumes by protons and HZE particles: geometric patterns of initial distributions of DNA repair foci


Galactic Cosmic Ray Event-Based Risk Model (GERM) Code


GERMcode: A Stochastic Model for Space Radiation Risk Assessment


The Analysis of the Patterns of Radiation-Induced DNA Damage Foci by a Stochastic Monte Carlo Model of DNA Double Strand Breaks Induction by Heavy Ions and Image Segmentation Software


Changes in Liver Metabolic Gene Expression after Radiation Exposure


Analysis of Terminal Deletions using a Generalized Time-Dependent Model of Radiation-Induced Formation of Chromosomal Aberrations


The Metabolic Cost of a High Intensity Exercise Program During Bed Rest


New Modeling Approaches to Investigate Cell Signaling in Radiation Response


The Distribution of Chromosomal Aberrations in Human Cells Predicted by a Generalized Time-Dependent Model of Radiation-Induced Formation of Aberrations


A Stochastic Model of Space Radiation Transport as a Tool in the Development of Time-Dependent Risk Assessment


Computational model of chromosome aberration yield induced by high- and low-LET radiation exposures


Nuclear interactions in heavy ion transport and event-based risk models


3D visualisation of the stochastic patterns of the radial dose in nano-volumes by a Monte Carlo simulation of HZE ion track structure


The analysis of the densely populated patterns of radiation-induced foci by a stochastic, Monte Carlo model of DNA double-strand breaks induction by heavy ions


Analysis of Flow Cytometry DNA Damage Response Protein Activation Kinetics after Exposure to X Rays and High-Energy Iron Nuclei


A model of the effects of heavy ion radiation on human tissue  Original Research Article


Phase distribution of products of radiation and post-radiation distillation of biopolymers: Cellulose, lignin and chitin Original Research Article


Development of a GCR Event-based Risk Model

   

Ryder, Jeffrey

Sildenafil increases muscle protein synthesis and reduces muscle fatigue


Integrated resistance and aerobic exercise protects fitness during bed rest


Use It or Lose It: Skeletal Muscle Function and Performance Results from Space Shuttle


Muscle Adaptations Following Short-Duration Bed Rest with Integrated Resistance, Interval, and Aerobic Exercise


Functional Task Test: 3. Skeletal Muscle Performance Adaptations to Space Flight


Influence of muscle strength to weight ratio on functional task performance

   

Saha, Janapriya

Lipofection and nucleofection of substrate plasmid can generate widely different readings of DNA end-joining efficiency in different cell lines


Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways


Differential Processing of Low and High LET Radiation Induced DNA Damage: Investigation of Switch from ATM to ATR Signaling


Protons sensitize epithelial cells to mesenchymal transition


Theoretical prediction of the binding free energy for mutants of replication protein A

   

Scott, Jessica

Exercise as potential countermeasure for the effects of 70 days of bed rest on cognitive and sensorimotor performance


Exercise as potential countermeasure for the effects of 70 days of bed rest on cognitive and sensorimotor performance


Autonomic dysfunction in early breast cancer: Incidence, clinical importance, and underlying mechanisms


Determinants of exercise intolerance in patients with heart failure and reduced or preserved ejection fraction


Letter by Scott and Haykowsky Regarding Articles, "Can Intensive Exercise Harm the Heart? The Benefits of Competitive Endurance Training for Cardiovascular Structure and Function" and "Can Intensive Exercise Harm the Heart? You Can Get Too Much of a Good Thing".


A framework for prescription in exercise-oncology research


Cardiovascular Function and Exercise Capacity in Patients With Colorectal Cancer : Does Anticancer Therapy Matter?


Reliability of Maximal Cardiopulmonary Exercise Testing in Men with Prostate Cancer


Utility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients treated with doxorubicin-containing adjuvant therapy


Cancer therapy-induced autonomic dysfunction in early breast cancer: implications for aerobic exercise training


The metabolic cost of an integrated exercise program performed during 14 days of bed rest


Chronology of KSC and KSC Related Events for 2012


Cancer therapy-induced cardiac toxicity in early breast cancer: addressing the unresolved issues


The Metabolic Cost of a High Intensity Exercise Program During Bed Rest


Synthesis of Coastal Ecosystem Science Studies on Sensitivity and Spatial Resolution for GEO-CAPE


Evaluation of tele-ultrasound as a tool in remote diagnosis and clinical management at the Amundsen-Scott South Pole Station and the McMurdo Research Station


Exercise therapy as treatment for cardiovascular and oncologic disease after a diagnosis of early-stage cancer


The Potential Role of Aerobic Exercise to Modulate Cardiotoxicity of Molecularly Targeted Cancer Therapeutics


Muscle Adaptations Following Short-Duration Bed Rest with Integrated Resistance, Interval, and Aerobic Exercise


Reliability of Peak Exercise Testing in Patients With Heart Failure With Preserved Ejection Fraction


Reliability and validity of panoramic ultrasound for muscle quantification


Changes in self-reported knee function and health-related quality of life after knee injury in female athletes


Cardiopulmonary function and age-related decline across the breast cancer survivorship continuum


A meta-analysis of the effects of exercise training on left ventricular remodeling following myocardial infarction: start early and go longer for greatest exercise benefits on remodeling


Effects of high intensity exercise on biventricular function assessed by cardiac magnetic resonance imaging in endurance trained and normally active individuals


Characterization of the relationship between systolic shear strain and early diastolic shear strain   rates: insights into torsional recoil


Measurements of changes in left ventricular volume, strain, and twist during isovolumic relaxation using MRI


Changes in ventricular twist and untwisting with orthostatic stress: endurance athletes versus normally active individuals


Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms


A meta-analysis of randomized control trials of home-based secondary prevention programs for coronary artery disease


Effect of exercise training on peak oxygen consumption in patients with cancer: a meta-analysis


Exercise therapy in the management of solid tumors


Upper limits of physiological cardiac adaptation in ultramarathon runners


Challenges, concerns and common problems: physiological consequences of spinal cord injury and microgravity

   

Sognier, Marguerite

Methods and apparatus for microwave tissue welding for wound closure


Improved Cell Culture Method for Growing Contracting Skeletal Muscle Models


Microwave Tissue Soldering for Immediate Wound Closure


No drill dentistry: Improved composites and in vivo studies, Biennial Research and Technology Report


Microwave-based water decontamination system, Biennial Research and Technology Report

   

Sulzman, Frank

From mice and men to earth and space: joint NASA-NCI workshop on lung cancer risk resulting from space and terrestrial radiation

   

Todd, William (Bill)

Multiplatform Ocean Exploration: Insights From the NEEMO Space Analog Mission

   

Wang, Minli

Investigation of switch from ATM to ATR signaling at the sites of DNA damage induced by low and high LET radiation


DNA Ligases I and III Cooperate in Alternative Non-Homologous End-Joining in Vertebrates


Lipofection and nucleofection of substrate plasmid can generate widely different readings of DNA end-joining efficiency in different cell lines


Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways


Radiation Carcinogenesis Risk Assessments for Never-smokers


Modularized Smad-regulated TGFβ signaling pathway


Protons sensitize epithelial cells to mesenchymal transition


Combining Heavy Ion Radiation and Artificial MicroRNAs to Target the Homologous Recombination Repair Gene Efficiently Kills Human Tumor Cells


Pathway Model of the Kinetics of the TGFbeta Antagonist Smad7 and Cross-Talk with the ATM and WNT Pathways


Space Radiation Cancer, Circulatory Disease and CNS Risks for Near Earth Asteroid and Mars Missions: Uncertainty Estimates for Never-Smokers


Widespread dependence of backup NHEJ on growth state: ramifications for the use of DNA-PK inhibitors


Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair


Heavy Ions Can Enhance TGFβ Mediated Epithelial to Mesenchymal Transition


Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells

   

Westby, Christian

Gradient compression garments protect against orthostatic intolerance during recovery from bed rest


Abdomen-high elastic gradient compression garments during post-spaceflight stand tests


Cardiovascular Adaptations in the Spaceflight Environment


Lower Limb Venous Compliance is Different Between Men and Women Following 60 Days of Head-Down Bedrest but Is Not Associated with Venoconstriction Dysfunction


Effects of High Dietary HEME Iron and Radiation on Cardiovascular Function


Effects and Responses to Spaceflight in the Mouse Retina


Compression Stockings May Ameliorate Orthostatic Intolerance in Astronauts After Short-Duration Space Flight


Gradient Compression Stockings may Prevent Recovery after Bed Rest Deconditioning


A Data Mining Project to Identify Cardiovascular Related Factors That May Contribute to Changes in Visual Acuity Within the US Astronaut Corps


Defining the Relationship Between Biomarkers of Oxidative and Inflammatory Stress and the Risk for Atherosclerosis in Astronauts During and After Long-Duration Spaceflight


Induction of a Radio-Adaptive Response by Low-dose Gamma Irradiation in Mouse Cardiomyocytes


Effects of endothelin-1 on endothelial progenitor cell function


Elevated endothelin-1 vasoconstrictor tone in prehypertensive adults


Enhanced endothelin-1 system activity with overweight and obesity


Endothelin-1 vasoconstriction and the age-related decline in endothelium-dependent vasodilatation in men


Short sleep duration is associated with enhanced endothelin-1 vasoconstrictor tone


Osteopenia and endothelin-1-mediated vasconstrictor tone in postmenopausal women


Regular aerobic exercise, without weight loss, improves endothelium-dependent vasodilation in overweight and obese adults


Endothelial progenitor cell function, apoptosis, and telomere length in overweight/obese humans


Sex differences in endothelin-1-mediated vasoconstrictor tone in middle-aged and older adults


Effects and Responses to Spaceflight in the Mouse Retina


Radio-Adaptive Responses of Mouse Myocardiocytes


60 Days of Head-down Bedrest Differentially Alters Venous Function in Lower and Upper Body Between Healthy Men and Women


Next-generation anti-gravity suits, Biennial Research and Technology Report

   

Wotring, Virginia

Wotring, Virginia. Book. Space Pharmacology, SpringerBriefs in Space Development Series; 2012


Therapeutic Options for Controlling Fluids in the Visual System


Career Exploration Program Exit Presentation


Pharmagology During Spaceflight Missions


Expression of Enzymes that Metabolize Medications


Pharmacology in Spaceflight


Changes in Liver Metabolic Gene Expression from Radiation Exposure


Pharmacological Issues for Astronauts


Radioadaptive Cytoprotective Pathways in the Mouse Retina


   

Yarbough, Patrice

Ocular outcomes evaluation in a 14-day head-down bed rest study


Association Between Cardiovascular and Intraocular Pressure Changes in a 14-Day 6 deg Head Down Tilt (HDT) Bed Rest Study: Possible Implications in Retinal Anatomy


Evaluation of Ocular Outcomes in Two 14-day Bed Rest Studies


Feasibility  Study of a Lunar Analog Bed Rest Model


Comparison of Ocular Outcomes in Two 14-Day Bed Rest Studies

   

Zanello, Susana

Molecular effects of spaceflight in the mouse eye after space shuttle mission STS-135


Ocular outcomes evaluation in a 14-day head-down bed rest study


Retinal non-visual photoreception in space


Spaceflight and the Mouse Eye: Results from Experiments on Shuttle Missions STS-133 and STS-135


Association Between Cardiovascular and Intraocular Pressure Changes in a 14-Day 6 deg Head Down Tilt (HDT) Bed Rest Study: Possible Implications in Retinal Anatomy


Evaluation of Ocular Outcomes in Two 14-day Bed Rest Studies


Mechanical Stress and Antioxidant Protection in the Retina of Hindlimb Suspended Rats


Effects of 30-day head-down bed rest on ocular structures and visual function in a healthy subject


Outcome measure to assess head-down bed rest subject performance


Contribution of Spaceflight Environmental Factors to Vision Risks


Molecular Mechanisms of Circadian Regulation During Spaceflight


Effects and Responses to Spaceflight in the Mouse Retina


Radioadaptive Cytoprotective Pathways in the Mouse Retina


A Glimpse of Space Exploration and the Challenges of Life Away from Earth


Simulated microgravity does not alter myogenesis gene expression in C2C12 cells


Comparison of Ocular Outcomes in Two 14-Day Bed Rest Studies

   

Zwart, Sara

Bone metabolism and renal stone risk during International Space Station missions


Magnesium and Space Flight


Bone metabolism and renal stone risk during International Space Station missions


Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes


Space Environmental Factor Impacts upon Murine Colon Microbiota and Mucosal Homeostasis


Evidence Report: Risk Factor of Inadequate Nutrition


Body mass changes during long-duration spaceflight


Body mass changes during long-duration spaceflight: response


Smith SM, Zwart SR, Heer M. Book. Human Adaptation to Spaceflight: The Role of Nutrition. NASA; 2014


Sex-specific responses of bone metabolism and renal stone risk during bed rest


Plasma Cytokine Concentrations Indicate That In Vivo Hormonal Regulation of Immunity Is Altered During Long-Duration Spaceflight


Calcium kinetics during bed rest with artificial gravity and exercise countermeasures


Calcium kinetics during bed rest with artificial gravity and exercise countermeasures


Fifty years of human space travel: implications for bone and calcium research


Lane HW, Zwart SR, Kloeris V, Smith SM. (2013). Ch. 25: Food and nutrition for space flight. In: Berdanier CD, Dwyer JT, and Heber D, eds. Handbook of Nutrition and Food. 3rd ed.  New York: CRC Press. Print ISBN: 978-1-4665-0571-1; eBook ISBN: 978-1-4665-0572-8 pp: 381-402, 2013


Men and Women in Space: Bone Loss and Kidney Stone Risk after Long-Duration Spaceflight


Increased dietary iron and radiation in rats promote oxidative stress, induce localized and systemic immune system responses, and alter colon mucosal environment


Smith SM, Zwart SR, Huntoon CL. Endocrinology (Chapter 4.8). (2013) In: Biomedical Results of the Space Shuttle Program, Risin D, Stepaniak P (eds.), Washington DC: U.S. Government Printing Office, NASA/SP-2013-607. ISBN: 978-0-615-86613-0, pp. 157-170


Zwart SR, Smith SM. Chapter 5.1. Nutrition. (2013) In: Biomedical Results of the Space Shuttle Program, Risin D, Stepaniak P (eds.), Washington DC: U.S. Government Printing Office, NASA/SP-2013-607. ISBN: 978-0-615-86613-0, pp. 267-74


Iron status and its relations with oxidative damage and bone loss during long-duration space flight on the International Space Station


Bichemical Profile


Effects of Dietary Iron and Gamma Radiation on the Rat Retina]


Immune System Dysregulation Persists During Long-Duration Spaceflight


A 250 μg/week dose of vitamin D was as effective as a 50 μg/d dose in healthy adults, but a regimen of four weekly followed by monthly doses of 1250 μg raised the risk of hypercalciuria


Space flight calcium: implications for astronaut health, spacecraft operations, and Earth


Co-Authored "Space Nutrition," an iBook (available as a free download on an iPad) for upper elementary school kids about the topic of Space Nutrition. 


High Dietary Iron and Radiation Exposure Increase Biomarkers of Oxidative Stress in Blood and Liver of Rats


High dietary iron and 137Cs radiation exposure induce oxidative stress and reduce bone mass


High Protein Intake Improves Insulin Sensitivity but Exacerbates Bone Resorption in Immobility (WISE Study)


Plasma Cytokine Levels During Long-Duration Spaceflight


Combined Effects of Gamma Radiation and High Dietary Iron on Peripheral Leukocyte Distribution and Function


Vision Changes after Space Flight Are Related to Alterations in Folate-Dependent One-Carbon Metabolism


Assessment of Nutritional Intake During Space Flight and Space Flight Analogs


Urinary Acid Excretion Can Predict Changes in Bone Metabolism During Space Flight


Evaluation of the Combined Effects of Gamma Radiation and High Dietary Iron on Peripheral Leukocyte Distribution and Function


Plasma Cytokine Levels During Long-Duration Spaceflight


Bone Metabolism and Nutritional Status during 30-day Head-Down Tilt Bed Rest


Benefits for bone from resistance exercise and nutrition in long-duration spaceflight: Evidence from biochemistry and densitometry


Saturation diving alters folate status and biomarkers of DNA damage and repair


Response to vitamin D supplementation during Antarctic winter is related to BMI, and supplementation can mitigate Epstein-Barr Virus Reactivation


Capacity of omega-3 fatty acids or eicosapentaenoic acid to counteract weightlessness-induced bone loss by inhibiting NF-kappaB activation: from cells to bed rest to astronauts


Response to vitamin D intake: from the Antarctic to the Institute of Medicine


Vitamin K status in spaceflight and ground-based models of spaceflight


Thyroid status of Space Shuttle crewmembers: effects of iodine removal


Long-Duration Space Flight and Bed Rest Effects on Testosterone and Other Steroids


Vision changes after spaceflight are related to alterations in folate- and vitamin B12-dependent one-carbon metabolism


Vitamin D: From the Antarctic to the International Space Station to North America, Biennial Research and Technology Report


Nutritional countermeasures to space-flight related stress. In: A Chouker (ed.)Stress challenges and immunity in space: from mechanisms to monitoring and protective strategies


Saturation diving alters folate status and biomarkers of DNA damage and repair